I-Amphotericin B 1397-89-3 I-Antibiotic
Inkokhelo:T/T, L/C
Umsuka Womkhiqizo:China
Imbobo yokuthutha:Beijing/Shanghai/Hangzhou
Amandla okukhiqiza:100kg/ngenyanga
I-oda(MOQ):25kg
Isikhathi esiholayo:3 Izinsuku Zokusebenza
Isimo sesitoreji:nesikhwama seqhwa sokuthutha.Gcina ku-2-8℃ isikhathi eside.
Impahla yephakheji:isigubhu
Usayizi wephakheji:25kg/isigubhu
Ulwazi lokuphepha:Akuzona izimpahla eziyingozi
Isingeniso
I-Amphotericin B, ingabizwa ngokuthi i-Fungizone noma i-Ambisome, okuyi-polyene antifungal antibiotic ehlukanisiwe nesiko le-Streptomycesnodosus.Ihlukaniswe izingxenye ezimbili ezino-A no-B, kodwa ingxenye ethi A iwumsebenzi omncane we-antifungal engasetshenziswa, ngakho abantu basebenzisa ingxenye engu-B kuphela ebizwa ngokuthi i-Amphotericin B.
Kuwumuthi we-antifungal osetshenziselwa izifo ezinzima zesikhunta kanye ne-leishmaniasis.Inokusetshenziswa okubili okuhlukene ngomlomo nangomjovo.
I-Amphotericin B iyinketho yokuqala yokutheleleka kwefungal okujulile ngenxa yobubanzi bayo be-antifungal spectrum.Inomsebenzi ovimbela ukhunta njenge-cryptococcus, coccidium, candida albicans nama-blastomycetes, njll. Izobulala i-fugal ekugxilweni okuphezulu, okuwumuthi osebenzayo wokwelapha ukutheleleka kwefungal okujulile.
Izinkomba zomtholampilo eziyinhloko ezifana nalezi: 1. Ukwelashwa kwesikhunta njenge-cryptococcosis, i-blastomycosis yaseNyakatho Melika, i-candidiasis esakazwayo, i-coccidiosis kanye ne-histoplasmosis.2. Ukwelashwa kwe-mucormycosis okubangelwa ezinye isikhunta njenge-Rhizopus, i-colporium, i-endomycetes kanye nesikhunta se-frog fecal.3. Ukwelashwa kwe-sporotrichosis okubangelwa i-sporotrichosis schenckii.4. Ukwelashwa kwe-aspergillosis ebangelwa i-Aspergillus fumigatus.5. Amalungiselelo e-topical afanele i-mycosis enemibala.Ilungele futhi ukutheleleka kwesikhunta esikhumbeni ngemva kokusha, ukuphefumula kwe-Candida kanye ne-Aspergillus noma ukutheleleka kwe-cryptococcus, kanye nokusebenza kwe-fungal cornea ulcer.
Imiphumela engemihle evamile ihlanganisa ukusabela ngomkhuhlane, ukugodola, kanye nekhanda elibuhlungu ngemva nje kokuba umuthi unikezwe, kanye nezinkinga zezinso.Izimpawu zokungezwani komzimba ezihlanganisa i-anaphylaxis zingenzeka.Eminye imiphumela emibi kakhulu ihlanganisa i-potassium ephansi yegazi nokuvuvukala kwenhliziyo.Kubonakala sengathi kuphephile uma ukhulelwe.Kukhona ukwakheka kwe-lipid enengozi ephansi yemiphumela emibi.Isesigabeni semithi ye-polyene futhi isebenza ngokwengxenye ngokuphazamisa ulwelwesi lweseli lwesikhunta.Kumelwe kube ukuqaphela ukusetshenziswa lapho phezu kwezimo kwenzeka, ngoba ukusetshenziswa ukuphepha kumele kulandele iseluleko kubasebenzi bezokwelapha.
Ukucaciswa Kwebanga Lomlomo (Izinga Lendlu)
| Into | Ukucaciswa |
| Ukubukeka | Impushana ephuzi ukuya kuwolintshi-ophuzi, ayinaphunga noma icishe ingabi naphunga. |
| Ukuhlonza | IR, HPLC |
| pH | 4.0-6.0 |
| Ukulahlekelwa Ekumisweni | ≤5.0% |
| I-Sulfated Ash | ≤3.0% |
| Izinto Ezihlobene | ≤0.5% |
| 303nm | Ukungcola A (Amphotericin A) ≤5.0% Ukungcola komuntu ngamunye okungaziwa ≤1.0% |
| 383nm | Ukungcola B (Amphotericin X1) ≤4.0% Ukungcola komuntu ngamunye okungaziwa ≤2.0% |
| Ukungcola Okuphelele | ≤15.0% |
| Izincibilikisi ezisele | I-Methanol ≤0.3% I-acetone ≤0.5% |
| Isivivinyo | ≥850 amphotericin B amayunithi/mg wento eyomisiwe. |
Ukucaciswa Kwebanga Lomlomo (Izinga Lendlu)
| Into | Ukucaciswa |
| Ukubukeka | Impushana ephuzi ukuya kuwolintshi engenaphunga. |
| Ukuhlonza | IR, HPLC |
| Izinsalela ekushiseni | ≤0.5% |
| Izinto ezihlobene |
|
| Ku-303nm | I-Amphotericin A ≤2.0% |
| Ukungcola komuntu ngamunye okungaziwa ≤1.0% | |
| kwe 383nm | I-Amphotericin X1 ≤4.0% |
| Ukungcola komuntu ngamunye okungaziwa ≤2.0% | |
| Ukungcola okuphelele | ≤15.0% |
| Izincibilikisi ezisele | I-acetone ≤0.5% |
| I-Methanol ≤0.3% | |
| Umkhawulo we-Microbiological | Isibalo se-Aerobic microbial ≤1000cfu/g |
| Izikhunta nama-yeasts ≤100cfu/g | |
| I-Escherichia coli Ayikho ku-1g | |
| Ama-bacterium endotoxins | <1.0EU/mg |
| Isivivinyo | ≥850 amphotericin B amayunithi/mg, abalwe ngesisekelo esomisiwe |
