I-Orlistat 96829-58-2 Antiobesity Diet supplement
Inkokhelo:T/T, L/C
Umsuka Womkhiqizo:China
Imbobo yokuthutha:Beijing/Shanghai/Hangzhou
Amandla okukhiqiza:800kg/ngenyanga
I-oda(MOQ):25kg
Isikhathi esiholayo:3 Izinsuku Zokusebenza
Isimo sesitoreji:Igcinwe endaweni epholile, eyomile, izinga lokushisa legumbi.
Impahla yephakheji:isigubhu
Usayizi wephakheji:25kg/isigubhu
Ulwazi lokuphepha:Akuzona izimpahla eziyingozi
Isingeniso
I-Orlistat iyi-lipase inhibitor esebenza isikhathi eside futhi enamandla.Luyimpushana emhlophe noma ecishe ibe mhlophe ezingeni lokushisa legumbi, elingancibiliki emanzini, lincibilika ku-chloroform, futhi lincibilika kalula ku-ethanol.Ivimbela i-enzyme ngokwenza izibopho eziqinile nezindawo ezisebenzayo ze-serine ze-gastric lipase kanye ne-pancreatic lipase esiswini namathumbu amancane.
I-Orlistat iwuhlobo lwesidakamizwa esinciphisa isisindo se-lipase inhibitor.Kuyi-hydrated derivative ye-lipstatin, enganciphisa ukumuncwa kwamafutha okudla nokunciphisa isisindo.Lo mkhiqizo unokuvinjelwa okunamandla nokukhethayo kwe-gastric lipase kanye ne-pancreatic lipase, awunamthelela kwamanye ama-enzyme okugaya (i-amylase, i-trypsin, i-chymotrypsin) ne-phospholipase, futhi akuthinti ukumuncwa kwama-carbohydrate, amaprotheni nama-phospholipids.Ivimbela i-enzyme ikakhulukazi ngokubopha okuhlangene nezinsalela ze-serine ezindaweni ezisebenzayo ze-gastric lipase kanye ne-pancreatic lipase emgudwini wamathumbu, ivimbele i-hydrolysis ye-triacylglycerol, inciphise ukutholwa kwe-monoglyceride kanye ne-fatty acid yamahhala, futhi ngaleyo ndlela ilawule isisindo somzimba.Umuthi awumuncwa umgudu wamathumbu, futhi ukuvinjelwa kwe-lipase kuyabuyiselwa emuva.
Lo mkhiqizo futhi unomsebenzi wokulawula i-lipids yegazi.Inganciphisa i-triglyceride kanye ne-low-density lipoprotein cholesterol ku-serum yeziguli ezikhuluphele futhi ikhulise isilinganiso se-high-density lipoprotein kuya ku-low-density lipoprotein.
Uma i-orlistat ihlanganiswe nokudla okunekhalori ephansi, ifanele ukwelashwa kwesikhathi eside kwabantu abakhuluphele nabakhuluphele ngokweqile, okuhlanganisa nalabo asebehlakulele izici eziyingozi ezihlobene nokukhuluphala.Inomsebenzi wokulawula isisindo wesikhathi eside njengokuncipha kwesisindo, ukugcinwa kwesisindo kanye nokuvimbela ukubopha kabusha.Umtholampilo ubonisa ngokusobala ukuthi umsebenzi wokulawula isisindo uwusizo kakhulu ekusetshenzisweni kwesikhathi eside lapho udla noma ngemva kwehora elilodwa lokudla.
I-Orlistat inganciphisa izinga lezehlakalo lezinto eziyingozi ezihlobene nokukhuluphala kanye nezinye izifo ezihlobene nokukhuluphala, okuhlanganisa i-hypercholesterolemia, uhlobo lwesifo sikashukela sohlobo II, ukubekezelela i-glucose okuphazamisekile, i-hyperinsulinemia, umfutho wegazi ophakeme, kanye nokunciphisa okuqukethwe kwamafutha ezithweni.
Ukucaciswa (USP42)
| Into | Ukucaciswa |
| Ukuhlonza | I-HPLC, IR |
| Ukujikeleza okuqondile kokubona | -48.0°~-51.0° |
| Okuqukethwe kwamanzi | ≤0.2% |
| Izinto ezihlobene I | Inhlanganisela ehlobene ne-Orlistat A ≤0.2% |
| Izinto ezihlobene II | Inhlanganisela ehlobene ne-Orlistat B ≤0.05% |
| Izinto ezihlobene III
| I-Formylleucine ≤0.2% |
| Inhlanganisela ehlobene ne-Orlistat C ≤0.05% | |
| I-Orlistat evula indandatho ye-epimer ≤0.2% | |
| I-D-Leucine orlistat ≤0.2% | |
| Ukungcola komuntu ngamunye okungaziwa ≤0.1% | |
| Izinto ezihlobene IV | Inhlanganisela ehlobene ne-Orlistat D ≤0.2% |
| I-Orlistat evulekile ring amide ≤0.1% | |
| Izinto ezihlobene V | Inhlanganisela Ehlobene ne-Orlistat E ≤0.2% |
| Ukungcola okuphelele (I kuya ku-V) | ≤1.0% |
| Izincibilikisi ezisele | I-Methanol ≤0.3% |
| I-EtOAc ≤0.5% | |
| n-Heptane ≤0.5% | |
| Izinsalela ekushiseni | ≤0.1% |
| Izinsimbi ezinzima njenge-Pb | ≤20ppm |
| Ukuhlolwa kwe-HPLC | 98.0%~101.5% (kusisekelo se-anhydrous, i-solvent-free) |
