Izindaba

I-peptide yethusi nayo ibizwa ngokuthiGHK-cuiyinkimbinkimbi eyakhiwe yinhlanganisela yei-triptide-1kanye ne-ion yethusi.Idatha yocwaningo ibonisa ukuthi ithusi emzimbeni wesilwane lidlala indima ebalulekile ngezindlela ezahlukene, ikakhulukazi ngethonya lethusi kuma-enzyme e-antioxidant.Kunama-enzyme amaningi abalulekile emzimbeni womuntu nasesikhumbeni adinga ama-ion ethusi.Lawa ma-enzyme adlala indima ekwakhekeni kwezicubu ezixhumeneyo, i-anti-oxidation kanye nokuphefumula kwamangqamuzana.I-Copper nayo idlala indima yokubonisa, engathinta ukuziphatha kanye ne-metabolism yamaseli.Uma i-Copper peptide incibilika emanzini, ibonisa umbala oluhlaza okwesibhakabhaka wasebukhosini obuye ubize i-Blue Copper peptide emkhakheni wezimboni.

Ucwaningo lukhombisa ukuthi i-Copper peptide inezinzuzo eziningi ekunakekelweni kwesikhumba, esebenza kakhulu embonini yezimonyo.

1. Indima ye-peptide yethusi ekulungiseni kabusha isikhumba

Ucwaningo lukhombisa i-peptide yethusi ishintsha ama-metalloproteinase ahlukene ohlelweni lokwakhiwa kabusha kwesikhumba samagundane.Umsebenzi we-enzyme ukhuthaza ukubola kwamaprotheni e-matrix angaphandle, angalinganisa ukubola kwamaprotheni e-extracellular matrix (amaprotheni e-ECM) futhi avimbele ukulimala kwesikhumba ngokweqile.I-peptide yethusi yandisa i-proteoglycan eyinhloko.Umsebenzi wale proteoglycan ukuvimbela ukwakheka kwezibazi kanye nokunciphisa izinga le-transforming growth factor (TGF beta), okwandisa izibazi ngokulawula ukuhlanganiswa kwama-collagen fibrils.

2. Ivuselela ukwakheka kwe-collagen

Ukuhlola okuningi kuye kwaqinisekisa ukuthi i-tripeptide-1 ivuselela ukuhlanganiswa kwe-collagen, i-glycosaminoglycan ekhethiwe kanye ne-protein encane ye-glycan deproteinization.Ngaphezu kwalokho, ingakwazi futhi ukulawula ukuhlanganiswa kwama-metalloproteinase ahlobene.Amanye alawa ma-enzyme azosheshisa ukubola kwamaprotheni e-matrix angaphandle kwamaseli, kanti amanye angavimbela umsebenzi we-protease.Lokhu kubonisa ukuthi i-peptide yethusi ingalawula izinga lamaprotheni esikhumbeni.

3. Anti-inflammatory kanye ne-antioxidant

Kwatholakala ukuthi i-peptide yethusi ivimbela ukuvuvukala ngokunciphisa amazinga e-cytokines avuthayo njenge-TGF-beta ne-TNF-a esigabeni esibucayi.I-Tripeptide-1 futhi yehlisa ukulimala kwe-oxidative ngokulawula izinga lensimbi nokucisha imikhiqizo enobuthi ye-fatty acid lipid peroxidation.

4. Khuthaza ukuphulukiswa kwesilonda

Izifundo eziningi zezilwane ziye zaqinisekisa ukuthi i-peptide yethusi eluhlaza okwesibhakabhaka inamandla okuphulukisa amanxeba.Ocwaningweni lukanogwaja, i-peptide yethusi eluhlaza okwesibhakabhaka ingasheshisa ukuphulukiswa kwesilonda, ikhuthaze i-angiogenesis, futhi yandise okuqukethwe kwama-enzyme e-antioxidant egazini.

5. Buyisela ukusebenza kwamaseli awonakele

Ama-Fibroblasts angamaseli ayinhloko wokuphulukiswa kwesilonda nokuvuselelwa kwezicubu.Abagcini nje ngokuhlanganisa izingxenye ezihlukahlukene ze-matrix yangaphandle, kodwa futhi bakhiqize inani elikhulu lezici zokukhula.Ucwaningo olwenziwa ngo-2005 lwabonisa ukuthi i-tripeptide-1 ingabuyisela ukusebenza kwe-fibroblasts ene-irradiated.

I-Copper peptide iwuhlobo lwe-polypeptide enezakhiwo zokulwa nokuguga nokulungisa.Ayikwazi ukukhuthaza kuphela ukukhiqizwa kohlobo lwe-collagen I, IV kanye ne-VII, kodwa futhi ikhuthaze umsebenzi we-collagen synthesis cell fibroblast, okuyisithako esihle kakhulu sokulwa nokuguga.

Mayelana nokulungisa, i-peptide yethusi ingavikela ama-fibroblasts agqugquzelwa yi-UV, ithuthukise umsebenzi wayo, inciphise ukugcinwa kwe-MMP-1, ibhekane ngokuphumelelayo nezici zokuvuvukala ezikhiqizwa ukuzwela, igcine umsebenzi wokuvinjelwa kwesikhumba owonakele ngenxa ye-stimuli yangaphandle, futhi ine-anti enhle kakhulu. i-allergic kanye namandla apholile.I-peptide yethusi ihlanganisa ukulwa nokuguga nokulungisa, okuyinto engavamile kakhulu ezintweni zamanje zokulwa nokuguga nokulungisa.