I-Tacrolimus monohydrate 109581-93-3 Antibiotic
Inkokhelo:T/T, L/C
Umsuka Womkhiqizo:China
Imbobo yokuthutha:Beijing/Shanghai/Hangzhou
Amandla okukhiqiza:1kg/ngenyanga
I-oda(MOQ):1g
Isikhathi esiholayo:3 Izinsuku Zokusebenza
Isimo sesitoreji:Igcinwe endaweni epholile, eyomile, izinga lokushisa legumbi.
Impahla yephakheji:ibhodlela, ibhodlela
Usayizi wephakheji:1g/ibhodlela, 5/ibhodlela, 10g/ibhodlela, 50g/ibhodlela, 500g/ibhodlela
Ulwazi lokuphepha:UN 2811 6.1/PG 3
Isingeniso
I-Tacrolimus, isidakamizwa esivimbela ukuzivikela komzimba.Ngemuva kokufakelwa kwesitho se-allogeneic, ingozi yokwenqatshwa kwesitho iphakathi.Ukunciphisa ingozi yokwenqatshwa kwesitho, i-tacrolimus inikezwa.Umuthi ungadayiswa futhi njengomuthi we-topical ekwelapheni izifo ze-T-cell-mediated ezifana ne-eczema ne-psoriasis.Ingasetshenziselwa ukwelapha isifo samehlo esomile emakati nasezinjeni.
I-Tacrolimus ivimbela i-calcineurin, ehilelekile ekukhiqizeni i-interleukin-2, i-molecule ekhuthaza ukuthuthukiswa nokwanda kwama-T cell, njengengxenye yempendulo yomzimba efundwayo (noma eguquguqukayo).
Ukucaciswa (USP43)
| Into | Ukucaciswa |
| Ukubukeka | Impushana emhlophe emhlophe noma ecishe ibe mhlophe |
| Ukuhlonza | IR, HPLC |
| Ukuncibilika | Incibilika kakhulu ku-methanol, inyibilika ngokukhululekile ku-N,N dimethylformamide nasetshwaleni, cishe ekuncibilikeni emanzini. |
| Izinsalela ekushiseni | ≤0.10 % |
| Ukungcola okuphilayo (inqubo-2) | I-Ascomycin 19-epimer ≤0.10 % |
| I-Ascomycin ≤0.50% | |
| I-Desmethyl tacrolimus ≤0.10% | |
| I-Tacrolimus 8-epimer ≤0.15 % | |
| I-Tacrolimus 8-propyl analog ≤0.15 % | |
| Ukungcola okungaziwa -I ≤0.10 % | |
| Ukungcola okungaziwa -II ≤0.10 % | |
| Ukungcola okungaziwa -III ≤0.10 % | |
| Ukungcola okuphelele ≤1.00 % | |
| Ukuzungezisa kwe-Optical (ngokwesisekelo) (10mg/ml ku-N,Ndimethylformamide) | -110.0° ~ -115.0° |
| Okuqukethwe kwamanzi (nge-KF) | ≤4.0% |
| Izinyibilikisi ezisele (nge-GC) | I-acetone ≤1000ppm (Ngasendlini) |
| I-Di-isopropyl ether ≤100ppm (In-house) | |
| I-Ethyl ether ≤5000ppm | |
| I-Acetonitrile ≤410ppm | |
| I-Toluene ≤890ppm | |
| I-Hexane ≤290ppm | |
| Ukuhlolwa kwe-Microbial (endlini) | Isamba sesibalo se-aerobic microbial ≤100cfu/gm |
| Isamba semvubelo nesibalo sesikhunta ≤10cfu/gm | |
| Izidalwa ezishiwo (Amagciwane) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) kufanele zingabikho | |
| I-Assay (nge-HPLC) (ngesisekelo se-anhydrous ne-solvent free) | 98%~102% |
