I-Alprostadil 745-65-3 I-Hormone ne-endocrine
Inkokhelo:T/T, L/C
Umsuka Womkhiqizo:China
Imbobo yokuthutha:Beijing/Shanghai/Hangzhou
Amandla okukhiqiza:1kg/ngenyanga
I-oda(MOQ): 1g
Isikhathi esiholayo:3 Izinsuku Zokusebenza
Isimo sesitoreji:nesikhwama seqhwa sokuthutha, -20 ℃ sokugcina isikhathi eside
Impahla yephakheji:ibhodlela, ibhodlela
Usayizi wephakheji:1g/ibhodlela, 5/ibhodlela, 10g/ibhodlela, 50g/ibhodlela, 500g/ibhodlela
Ulwazi lokuphepha:UN 2811 6.1/PG 3
Isingeniso
I-Alprostadil, ebizwa nangokuthi i-Prostaglandin E1 noma i-PEG1.Itholakala kabanzi emzimbeni wezinto eziphilayo ezisebenzayo, njengomunye womndeni we-prostaglandin, iyinto eyaziwayo ye-endogenous physiologically esebenzayo.
Ingasetshenziswa ngokuqondile emisipha ebushelelezi ye-vascular, ukuze ivule imithambo yegazi futhi ikhulise ukugeleza kwegazi, okungathuthukisa ukuchithwa kwe-microcirculation.Ingavimbela ukuhlanganiswa kweplatelet kanye nokukhiqizwa kwe-thromboxane A2, futhi ivimbele i-atherosclerosis, i-lipid plaque kanye nokwakheka kwe-immune complex.
Ibuye ibe nemiphumela elandelayo: ekwandiseni imithambo yegazi emincane kanye nemithambo ye-coronary, ukunciphisa ukumelana ne-peripheral vascular kanye nomfutho wegazi.Ukuvikela ulwelwesi lweplatelet olungamelana ne-thrombosis.Ukuvikela i-ischemic myocardium, enganciphisa usayizi we-myocardial infarct.Isetshenziselwa ukwelapha ukwehluleka kwenhliziyo futhi.Inomsebenzi we-diuretic kanye nokuvikela izinso, okusekelwe ekwandiseni imithambo yegazi yezinso ukuze kwandiswe ukugeleza kwegazi kwezinso.Ngale ndlela, ingasusa i-nitrogen engeyona amaprotheni, futhi ilawule ibhalansi ye-sodium namanzi.
Kuyinto emtholampilo ukusetshenziswa kabanzi.Njengezinkinga zesifo sikashukela, isifo senhliziyo kanye nokuhluleka kwenhliziyo okungalawuleki.Futhi ukusetshenziswa esimweni esifana nesifo senhliziyo sokuzalwa esiyinkimbinkimbi ne-pulmonary hypertension, i-cerebral infarction kanye nesifo esingelapheki se-arterial occlusive.Kwezinye izimo njengokungezwa okungazelelwe, ukuvaleka kwemithambo ye-retinal, i-viral hepatitis noma i-gastritis engapheli, nayo inomsebenzi.Ingasebenza emtholampilo kwezinye izifo ezifana nesilonda se-duodenal, ukungasebenzi kahle kwezinso okungapheli kanye ne-pancreatitis.Kusetshenziswa ekufakweni kwezitho zomzimba.Isetshenziselwa ezinye izifo ezifana nokungasebenzi kahle kwe-erectile, ukungeniswa komsebenzi kanye ne-postpartum hemorrhage, i-femoral head necrosis, i-lumbar disc herniation, i-postherpetic neuralgia kanye ne-asthma ye-bronchial.
Kufanele kuqashelwe ukusetshenziswa ezigulini ezinesifo esifana nokuhluleka kwenhliziyo, i-glaucoma, isilonda se-peptic noma inyumoniya ye-interstitial.Ngomphumela ocasulayo kumthambo, uzobonisa izimpawu zokuvuvukala njengokubomvu, ukuvuvukala, ukushisa nobuhlungu, okungase kubangele i-phlebitis.Kufanele ime ukuze isetshenziselwe ukuphepha lapho kwenzeka isimo.
Ukucaciswa (USP43)
| Into | Ukucaciswa |
| Ukubukeka | Impushana ecwebezelayo emhlophe noma ephuzi kancane |
| Ukuhlonza | IR |
| Izinsalela ekushiseni | ≤0.5% |
| Umkhawulo we-chromium | ≤0.002% |
| Umkhawulo we-rhodium | ≤0.002% |
| Izinto ezihlobene | I-Prostaglandin A1 ≤1.5% |
| I-Prostaglandin B1 ≤0.1% | |
| Noma yikuphi ukungcola kwangaphandle kwe-prostaglandin okudlulayo ngaphambi kwe-prostaglandin A1 ≤0.9% | |
| Ukungcola ngesikhathi sokugcinwa okuhlobene 0.6, ngokuhlobene ne-prostaglandin A1 ≤0.9% | |
| Isamba sokungcola ngezikhathi zokugcinwa okuhlobene 2.0 kanye no-2.3 ≤0.6% | |
| Noma yikuphi okunye ukungcola kwe-prostaglandin yangaphandle okuphuma ngemuva kwe-prostaglandin A1 ≤0.9% | |
| Ukungcola okuphelele ≤2.0% | |
| Ukuzimisela kwamanzi | ≤0.5% |
| Izincibilikisi ezisele | I-Ethanol ≤5000ppm |
| I-acetone ≤5000ppm | |
| I-Dichloromethane ≤600ppm | |
| I-N-Hexane ≤290ppm | |
| I-N-Heptane ≤5000ppm | |
| I-Ethyl acetate ≤5000ppm | |
| I-Assay (ngokwesisekelo se-anhydrous) | 95.0%~105.0% |
