Izindaba

I-Alprostadil, ephinde yaqanjwa ngokuthi i-PGE1, iwuhlobo lwempahla eluhlaza yezemithi, esetshenziswa kakhulu kwezokwelapha nasezinkundleni ezihlobene.Itholakala njengomjovo noma ngendlela yama-suppositories nama-creams asezindaweni zokwelashwa.Njengenye yezingxenye eziyinhloko ezisetshenziselwa ukukhiqizwa kwe-prostaglandin E1 (PGE1) derivatives, i-alprostadil idlala indima ebalulekile ekwandiseni imithambo yegazi nokuthuthukisa ukugeleza kwegazi ezindaweni ezithile zezicubu ezigulini ezine-erectile dysfunction (ED).Ucwaningo lwezokwelapha luye lwaphetha ngokuthi i-alprostadil ithuthukisa ngempumelelo ukulungiswa ngokukhulula i-nitric oxide, evuselela amangqamuzana emisipha abushelelezi ahilelekile enqubweni yokumiswa.Ukwengeza, kuboniswe ukuthi kusebenza ngokushesha kakhulu kunemithi yendabuko yomlomo lapho ilawulwa nge-intracavernously noma intraurethrally.

Mayelana nesenzo semithi, i-alprostadil ngokuyinhloko isebenza njenge-agonist ye-prostaglandin receptor, futhi ama-prostaglandin receptors atholakala kuwo wonke umzimba womuntu.Lesi senzo sikhiqiza imiphumela efana ne-vasodilation, okuholela ekukhuleni kwegazi lendawo;i-bronchoconstriction ukunciphisa izimpawu ze-asthma;kungenzeka ukunciphisa i-apoptosis ezifweni ezihlobene nomdlavuza;ukunciphisa ukuvuvukala, nokunye.Izakhiwo zayo ezinemisebenzi eminingi ziyenza ibe isithako esifanelekile sezinhlelo eziningi zokuthuthukisa izidakamizwa, kusukela ekwelashweni kwe-ED kuya ekwelashweni komdlavuza nokunye, kuye ngenkinga ethile umkhiqizo wokugcina okufanele ubhekane nayo.

Ngaphezu kokwenzelwa izinjongo zokwelapha izifo ezahlukahlukene ngokusebenzisa izindlela zokuphatha ezifana nomjovo noma amafomu e-suppository;uma kuqhathaniswa nemikhiqizo efanayo emakethe, i-PGE1 iphinde ibonise imiphumela emibi emincane, kuhlanganise nekhanda elibuhlungu ngemva kokusetshenziswa, kuze kube Ubuthakathaka obuphelele ngemva kwamahora ambalwa;nakuba ngezinye izikhathi zenzeka, ngokuvamile azivamile ukwenziwa ngokunembile ngemithamo enqunyiwe, kuqala ngeziqondiso zokusetshenziswa kwesikhathi eside ezinikezwa ireferensi kadokotela ochazayo.Ngaphezu kwalokho, ngokocwaningo lwakamuva lwesayensi olwenziwa emhlabeni wonke, ngokuvamile, isikhathi sokuqala kwesenzo esigcwele siyahlukahluka ukusuka emaminithini angu-15 kuphela kuya kumkhawulo wemizuzu engu-30, kodwa ngokwemvelo imiphumela incike kakhulu esimweni sesiguli ngasinye.

Sekukonke, i-PGE1 ibonise umphumela onenzuzo emangalisayo, ikakhulukazi emadodeni anezinkinga zokuziphatha okubi zobulili kanye nezinkinga zesimo somzimba Izindlela zokwelapha ezinqunyiwe ngokwesiko zehlulekile ngenxa yokuntuleka kwamandla asebenzayo kanye nobunkimbinkimbi bezindaba zamanje budinga ukuxazululwa ngendlela efanele, ngaphandle kokukhathazeka nganoma iyiphi impilo engathi sína. izinkinga, ngokuyisisekelo okwenza kube inketho ephephile futhi esebenzayo.