I-Tulathromycin 217500-96-4 Antibiotic Antifungal
Inkokhelo:T/T, L/C
Umsuka Womkhiqizo:China
Imbobo yokuthutha:Beijing/Shanghai/Hangzhou
Amandla okukhiqiza:400kg/ngenyanga
I-oda(MOQ):25kg
Isikhathi esiholayo:3 Izinsuku Zokusebenza
Isimo sesitoreji:Igcinwe endaweni epholile, eyomile, izinga lokushisa legumbi.
Impahla yephakheji:isigubhu
Usayizi wephakheji:25kg/isigubhu
Ulwazi lokuphepha:Akuzona izimpahla eziyingozi
Isingeniso
I-Tulathromycin, iyi-ejenti elwa namagciwane ene-spectrum ebanzi enomsebenzi wokulwa namagciwane ngokumelene namagciwane athile egram-positive kanye ne-Gram-negative.Izwela kakhulu kumagciwane ezifo zokuphefumula ezinkomeni nasezingulubeni, njenge-Actinobacillus pleuropneumoniae, Pasteurella haemolyticus, Pasteurella haemorrhagica, histophilus sleep (Haemophilus sleep), Mycoplasma pneumoniae, Haemophilus parasuis, Bordetella bronchiseptica, njll.
Izici ze-pharmacokinetic ze-Tulathromycin ukuthi ngemuva kokuphathwa komthamo owodwa, imuncwa ngokushesha endaweni yomjovo, ukugcwala kwegazi okusebenzayo kugcinwa isikhathi eside, ukuqedwa kuhamba kancane, ivolumu yokusabalalisa ebonakalayo inkulu, i-bioavailability iphezulu, futhi ukugxiliswa kwezicubu ze-peripheral kungaphezu kwalokho ku-plasma.Ukusatshalaliswa okubanzi kwezicubu kanye nokungena kahle kwamaseli kuyizici ezibalulekile ze-Tulathromycin metabolism.Ukunqwabelana kumaseli omzimba nakho kuyisici esibalulekile seTulathromycin.
I-Tulathromycin ivimbela ukuhlanganiswa kwamaprotheni ebhaktheriya ngokuvimbela inqubo yokudlulisa i-peptide yebhaktheriya.Ngenxa yokukhubazeka okuthile okubalulekile kwe-erythromycin, abantu badinga omunye umuthi esikhundleni se-erythromycin ngokushesha.I-Tulathromycin uhlobo olusha lwe-macrolide semi synthetic antibiotic yezilwane.Inezinzuzo eziningi, njengomthamo ophansi, ukuphathwa kwesikhathi esisodwa, izinsalela eziphansi, isilwane esithile nokunye.Ayinayo nje inzuzo yezidakamizwa ze-macrolide, kodwa futhi ine-ultra long half-life ephakeme kunamanye ama-macrolide antibiotics.Ngokusekelwe enzuzweni yokugcina ukugxila kokwelapha okusebenzayo emzimbeni isikhathi eside, kungafinyelela i-bacteriostasis engcono kanye nenzalo.
Ngemuva kokusetshenziswa okubanzi komtholampilo, i-tulathromycin inomphumela osobala wezokwelapha ezifweni zokuphefumula zezinkomo nezingulube.Siyabonga ngomsebenzi omuhle kakhulu we-antibacterial we-Tulathromycin njengokusebenzisa umthamo omncane, uhhafu wempilo ende kanye nokuphatha isikhathi esisodwa, ingasetshenziswa kabanzi.
I-Tulathromycin inamandla kunama-macrolides asetshenziswa kabanzi emakethe njengamanje, njenge-tylosin, i-tilmicosin ne-florfenicol.Enezinhlelo zokusebenza ezinkulu ezingaba khona.
Kufanele kuqashelwe ukuthi i-Tulathromycin iphephile uma kuqhathaniswa, ngaphandle kwe-carcinogenicity, i-teratogenicity kanye ne-genotoxicity.Ngeke ibangele ukuguqulwa kwezakhi zofuzo, kodwa ingase ikhiqize i-cardiotoxicity.Kudingeka ukulandela iseluleko sezilwane.
Ukucaciswa (In House Standard)
| Into | Ukucaciswa |
| Ukubukeka | Impushana emhlophe noma ecishe ibe mhlophe |
| Ukuncibilika | Incibilika ngokukhululekile ku-methanol, i-acetone, ne-methyl acetate, inyibilika ku-ethanol. |
| Ukujikeleza okuqondile kokubona | -22° kuya ku-26° |
| Ukuhlonza | I-HPLC: isikhathi sokugcina sesiqongo esikhulu ku-chromatogram yokulungiselela i-assay sihambisana naleyo eku-chromatogram yokulungiswa kwe-strandard etholwe njengoba kucacisiwe ku-assay. IR: I-spectrum ye-IR ihambisana ne-CRS |
| Amanzi | ≤2.5% |
| Izinsalela ekushiseni | ≤0.10% |
| Izinsimbi ezinzima | ≤20ppm |
| Into ehlobene | Ukungcola okuphelele ≤6.0% Ukungcola komuntu ngamunye ≤3.0% |
| I-endotoxin yebhaktheriya | < 2 EU |
| I-Assay (into engenamanzi) | 95%-103% |
| I-solvent eyinsalela | I-N-Heptane≤5000ppm I-Dichloromethane ≤600ppm |
| Isivivinyo | Okuqukethwe kwe-C41H79N3O12: 95% -103% (Entweni ye-Anydrous) |
